<?xml version="1.0" encoding="utf-8"?>
<!--XBRL document created with Toppan Merrill Bridge  10.3.0.9 -->
<!--Based on XBRL 2.1-->
<!--Created on: 8/10/2023 3:04:39 PM-->
<!--Modified on: 8/10/2023 3:04:39 PM-->
<xsd:schema targetNamespace="http://www.rigetti.com/20230630" elementFormDefault="qualified" xmlns="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:us-gaap="http://fasb.org/us-gaap/2023" xmlns:country="http://xbrl.sec.gov/country/2023" xmlns:currency="http://xbrl.sec.gov/currency/2023" xmlns:dei="http://xbrl.sec.gov/dei/2023" xmlns:exch="http://xbrl.sec.gov/exch/2023" xmlns:naics="http://xbrl.sec.gov/naics/2023" xmlns:sic="http://xbrl.sec.gov/sic/2023" xmlns:us-types="http://fasb.org/us-types/2023" xmlns:stpr="http://xbrl.sec.gov/stpr/2023" xmlns:srt="http://fasb.org/srt/2023" xmlns:srt-types="http://fasb.org/srt-types/2023" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:deprecated="http://www.xbrl.org/2009/role/deprecated" xmlns:dtr="http://www.xbrl.org/2009/dtr" xmlns:ref="http://www.xbrl.org/2006/ref" xmlns:utr="http://www.xbrl.org/2009/utr" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:us-roles="http://fasb.org/us-roles/2023" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:attributeFormDefault="unqualified" xmlns:srt-roles="http://fasb.org/srt-roles/2023" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:rgti="http://www.rigetti.com/20230630">
  <xsd:annotation>
    <xsd:appinfo>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureStandardAndCustomAxisDomainDefaults" id="DisclosureStandardAndCustomAxisDomainDefaults">
        <link:definition>99900 - Disclosure - Standard And Custom Axis Domain Defaults</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/StatementInterimCondensedConsolidatedBalanceSheets" id="StatementInterimCondensedConsolidatedBalanceSheets">
        <link:definition>00100 - Statement - INTERIM CONDENSED CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/StatementInterimCondensedConsolidatedStatementsOfOperations" id="StatementInterimCondensedConsolidatedStatementsOfOperations">
        <link:definition>00200 - Statement - INTERIM CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/StatementInterimCondensedConsolidatedStatementsOfComprehensiveLoss" id="StatementInterimCondensedConsolidatedStatementsOfComprehensiveLoss">
        <link:definition>00300 - Statement - INTERIM CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/StatementInterimCondensedConsolidatedStatementsOfCashFlows" id="StatementInterimCondensedConsolidatedStatementsOfCashFlows">
        <link:definition>00400 - Statement - INTERIM CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureBusinessCombinationSummaryOfNetProceedsFromBusinessCombinationAndPipeFinancingDetail" id="DisclosureBusinessCombinationSummaryOfNetProceedsFromBusinessCombinationAndPipeFinancingDetail">
        <link:definition>40301 - Disclosure - BUSINESS COMBINATION - Summary of Net proceeds from Business Combination and PIPE financing (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureInvestmentsSummaryOfFairValueOfAvailableForSaleSecuritiesDetail" id="DisclosureInvestmentsSummaryOfFairValueOfAvailableForSaleSecuritiesDetail">
        <link:definition>40701 - Disclosure - INVESTMENTS - Summary of Fair Value of Available For Sale Securities (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFinancingArrangementsLongTermDebtAndUnamortizedDiscountDetail" id="DisclosureFinancingArrangementsLongTermDebtAndUnamortizedDiscountDetail">
        <link:definition>41001 - Disclosure - FINANCING ARRANGEMENTS - Long term debt and the unamortized discount (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFinancingArrangementsScheduledPrincipalPaymentsOnTotalOutstandingDebtDetail" id="DisclosureFinancingArrangementsScheduledPrincipalPaymentsOnTotalOutstandingDebtDetail">
        <link:definition>41002 - Disclosure - FINANCING ARRANGEMENTS - Scheduled principal payments on total outstanding debt (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DocumentCoverPage" id="DocumentCoverPage">
        <link:definition>00090 - Document - Cover Page</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/StatementInterimCondensedConsolidatedBalanceSheetsParenthetical" id="StatementInterimCondensedConsolidatedBalanceSheetsParenthetical">
        <link:definition>00105 - Statement - INTERIM CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureDescriptionOfBusiness" id="DisclosureDescriptionOfBusiness">
        <link:definition>10101 - Disclosure - Description of Business</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRevenueRecognition" id="DisclosureRevenueRecognition">
        <link:definition>10601 - Disclosure - REVENUE RECOGNITION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFairValueMeasurements" id="DisclosureFairValueMeasurements">
        <link:definition>10801 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFinancingArrangements" id="DisclosureFinancingArrangements">
        <link:definition>11001 - Disclosure - FINANCING ARRANGEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureCommonStock" id="DisclosureCommonStock">
        <link:definition>11101 - Disclosure - COMMON STOCK</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureWarrants" id="DisclosureWarrants">
        <link:definition>11201 - Disclosure - WARRANTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureForwardWarrantAgreement" id="DisclosureForwardWarrantAgreement">
        <link:definition>11301 - Disclosure - FORWARD WARRANT AGREEMENT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureNetLossPerShare" id="DisclosureNetLossPerShare">
        <link:definition>11501 - Disclosure - NET LOSS PER SHARE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureIncomeTaxes" id="DisclosureIncomeTaxes">
        <link:definition>11601 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRevenueRecognitionTables" id="DisclosureRevenueRecognitionTables">
        <link:definition>30603 - Disclosure - REVENUE RECOGNITION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFairValueMeasurementsTables" id="DisclosureFairValueMeasurementsTables">
        <link:definition>30803 - Disclosure - FAIR VALUE MEASUREMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureShareBasedCompensationTables" id="DisclosureShareBasedCompensationTables">
        <link:definition>30903 - Disclosure - SHARE-BASED COMPENSATION - (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureCommonStockTables" id="DisclosureCommonStockTables">
        <link:definition>31103 - Disclosure - COMMON STOCK (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureWarrantsTables" id="DisclosureWarrantsTables">
        <link:definition>31203 - Disclosure - WARRANTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureForwardWarrantAgreementTables" id="DisclosureForwardWarrantAgreementTables">
        <link:definition>31303 - Disclosure - FORWARD WARRANT AGREEMENT (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureConcentrationsSignificantCustomersAndGeographicAreasTables" id="DisclosureConcentrationsSignificantCustomersAndGeographicAreasTables">
        <link:definition>31403 - Disclosure - CONCENTRATIONS, SIGNIFICANT CUSTOMERS AND GEOGRAPHIC AREAS - (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureNetLossPerShareTables" id="DisclosureNetLossPerShareTables">
        <link:definition>31503 - Disclosure - NET LOSS PER SHARE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureDescriptionOfBusinessAdditionalInformationDetail" id="DisclosureDescriptionOfBusinessAdditionalInformationDetail">
        <link:definition>40101 - Disclosure - Description of Business - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRecentAccountingDevelopmentsDetails" id="DisclosureRecentAccountingDevelopmentsDetails">
        <link:definition>40201 - Disclosure - RECENT ACCOUNTING DEVELOPMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureBusinessCombinationSummaryOfNetProceedsFromBusinessCombinationAndPipeFinancingParentheticalDetail" id="DisclosureBusinessCombinationSummaryOfNetProceedsFromBusinessCombinationAndPipeFinancingParentheticalDetail">
        <link:definition>40302 - Disclosure - BUSINESS COMBINATION - Summary of Net proceeds from Business Combination and PIPE financing (Parenthetical) (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureBusinessCombinationSummaryOfConsummationOfBusinessCombinationDetail" id="DisclosureBusinessCombinationSummaryOfConsummationOfBusinessCombinationDetail">
        <link:definition>40303 - Disclosure - BUSINESS COMBINATION - Summary of Consummation of the Business Combination (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureBusinessCombinationSummaryOfConsummationOfBusinessCombinationParentheticalDetail" id="DisclosureBusinessCombinationSummaryOfConsummationOfBusinessCombinationParentheticalDetail">
        <link:definition>40304 - Disclosure - BUSINESS COMBINATION - Summary of Consummation of the Business Combination (Parenthetical) (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureBusinessCombinationAdditionalInformationDetail" id="DisclosureBusinessCombinationAdditionalInformationDetail">
        <link:definition>40305 - Disclosure - BUSINESS COMBINATION - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureEarnOutLiabilitySummaryOfSignificantInputsOfEarnoutLiabilityBasedOnMonteCarloSimulationModelsDetail" id="DisclosureEarnOutLiabilitySummaryOfSignificantInputsOfEarnoutLiabilityBasedOnMonteCarloSimulationModelsDetail">
        <link:definition>40401 - Disclosure - EARN-OUT LIABILITY - Summary of Significant Inputs of Earnout Liability Based on Monte Carlo Simulation Models (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureChangesInStockholdersEquityDeficitSummaryOfReconciliationOfChangesInStockholdersEquityDetail" id="DisclosureChangesInStockholdersEquityDeficitSummaryOfReconciliationOfChangesInStockholdersEquityDetail">
        <link:definition>40501 - Disclosure - CHANGES IN STOCKHOLDERS' EQUITY(DEFICIT) - Summary of Reconciliation of Changes in Stockholders Equity (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRevenueRecognitionAdditionalInformationDetail" id="DisclosureRevenueRecognitionAdditionalInformationDetail">
        <link:definition>40601 - Disclosure - REVENUE RECOGNITION - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRevenueRecognitionSummaryOfDisaggregationOfRevenueDetail" id="DisclosureRevenueRecognitionSummaryOfDisaggregationOfRevenueDetail">
        <link:definition>40602 - Disclosure - REVENUE RECOGNITION - Summary of Disaggregation of Revenue (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRevenueRecognitionSummaryOfContractWithCustomerContractAssetContractLiabilityAndReceivableDetail" id="DisclosureRevenueRecognitionSummaryOfContractWithCustomerContractAssetContractLiabilityAndReceivableDetail">
        <link:definition>40603 - Disclosure - REVENUE RECOGNITION - Summary of Contract with Customer, Contract Asset, Contract Liability, and Receivable (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRevenueRecognitionSummaryOfChangeInContractWithCustomerAssetAndLiabilityDetail" id="DisclosureRevenueRecognitionSummaryOfChangeInContractWithCustomerAssetAndLiabilityDetail">
        <link:definition>40604 - Disclosure - REVENUE RECOGNITION - Summary of Change in Contract with Customer, Asset and Liability (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureInvestmentsAdditionalInformationDetail" id="DisclosureInvestmentsAdditionalInformationDetail">
        <link:definition>40702 - Disclosure - INVESTMENTS - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFairValueMeasurementsSummaryOfInformationAboutAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetail" id="DisclosureFairValueMeasurementsSummaryOfInformationAboutAssetsAndLiabilitiesMeasuredAtFairValueOnRecurringBasisDetail">
        <link:definition>40801 - Disclosure - FAIR VALUE MEASUREMENTS - Summary of Information About Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFairValueMeasurementsAdditionalInformationDetail" id="DisclosureFairValueMeasurementsAdditionalInformationDetail">
        <link:definition>40802 - Disclosure - FAIR VALUE MEASUREMENTS - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFairValueMeasurementsSummaryOfChangeInFairValueOfDerivativeLiabilitiesDetail" id="DisclosureFairValueMeasurementsSummaryOfChangeInFairValueOfDerivativeLiabilitiesDetail">
        <link:definition>40803 - Disclosure - FAIR VALUE MEASUREMENTS - Summary Of Change in Fair Value of Derivative Liabilities (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureShareBasedCompensationScheduleOfShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateIntrinsicValueDetail" id="DisclosureShareBasedCompensationScheduleOfShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGrantDateIntrinsicValueDetail">
        <link:definition>40901 - Disclosure - SHARE-BASED COMPENSATION - Schedule Of Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Grant Date Intrinsic Value (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureShareBasedCompensationScheduleOfActivityRelatedToRestrictedStockUnitsDetail" id="DisclosureShareBasedCompensationScheduleOfActivityRelatedToRestrictedStockUnitsDetail">
        <link:definition>40902 - Disclosure - SHARE-BASED COMPENSATION - Schedule of Activity Related to Restricted Stock Units (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureShareBasedCompensationScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsDetail" id="DisclosureShareBasedCompensationScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsDetail">
        <link:definition>40903 - Disclosure - SHARE-BASED COMPENSATION -Schedule Of Share Based Payment Award Stock Options Valuation Assumptions (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureShareBasedCompensationScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsDetail" id="DisclosureShareBasedCompensationScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsDetail">
        <link:definition>40904 - Disclosure - SHARE-BASED COMPENSATION - Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureShareBasedCompensationAdditionalInformationDetail" id="DisclosureShareBasedCompensationAdditionalInformationDetail">
        <link:definition>40905 - Disclosure - SHARE-BASED COMPENSATION - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFinancingArrangementsAdditionalInformationDetail" id="DisclosureFinancingArrangementsAdditionalInformationDetail">
        <link:definition>41003 - Disclosure - FINANCING ARRANGEMENTS - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureCommonStockSummaryOfConversionsOfStockDetail" id="DisclosureCommonStockSummaryOfConversionsOfStockDetail">
        <link:definition>41101 - Disclosure - COMMON STOCK - Summary of Conversions of Stock (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureCommonStockAdditionalInformationDetail" id="DisclosureCommonStockAdditionalInformationDetail">
        <link:definition>41102 - Disclosure - COMMON STOCK - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureWarrantsAdditionalInformationDetail" id="DisclosureWarrantsAdditionalInformationDetail">
        <link:definition>41201 - Disclosure - WARRANTS - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureWarrantsScheduleOfFairValueOfPrivatePlacementWarrantMeasuredUsingBlackScholesApproachDetail" id="DisclosureWarrantsScheduleOfFairValueOfPrivatePlacementWarrantMeasuredUsingBlackScholesApproachDetail">
        <link:definition>41202 - Disclosure - WARRANTS- Schedule Of Fair Value Of The Private Placement Warrant Measured Using Black Scholes Approach (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureWarrantsScheduleOfFairValueOfTrinityWarrantLiabilitiesMeasuredUsingBlackScholesApproachDetail" id="DisclosureWarrantsScheduleOfFairValueOfTrinityWarrantLiabilitiesMeasuredUsingBlackScholesApproachDetail">
        <link:definition>41203 - Disclosure - WARRANTS - Schedule Of Fair Value Of The Trinity Warrant liabilities Measured Using Black Scholes Approach (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureWarrantsSummaryOfVestingStatusOfCustomerWarrantDetail" id="DisclosureWarrantsSummaryOfVestingStatusOfCustomerWarrantDetail">
        <link:definition>41204 - Disclosure - WARRANTS - Summary of Vesting Status of the Customer Warrant (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureForwardWarrantAgreementAdditionalInformationDetail" id="DisclosureForwardWarrantAgreementAdditionalInformationDetail">
        <link:definition>41301 - Disclosure - FORWARD WARRANT AGREEMENT - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureForwardWarrantAgreementSummaryOfFairValueLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesDetail" id="DisclosureForwardWarrantAgreementSummaryOfFairValueLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesDetail">
        <link:definition>41302 - Disclosure - FORWARD WARRANT AGREEMENT - Summary of Fair Value Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureConcentrationsSignificantCustomersAndGeographicAreasSummaryOfCustomersRevenueAndReceivablesDetail" id="DisclosureConcentrationsSignificantCustomersAndGeographicAreasSummaryOfCustomersRevenueAndReceivablesDetail">
        <link:definition>41401 - Disclosure - CONCENTRATIONS, SIGNIFICANT CUSTOMERS AND GEOGRAPHIC AREAS - Summary of customers revenue and receivables (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureConcentrationsSignificantCustomersAndGeographicAreasSummaryOfRevenueByGeographyDetail" id="DisclosureConcentrationsSignificantCustomersAndGeographicAreasSummaryOfRevenueByGeographyDetail">
        <link:definition>41402 - Disclosure - CONCENTRATIONS, SIGNIFICANT CUSTOMERS AND GEOGRAPHIC AREAS - Summary of revenue by geography (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureConcentrationsSignificantCustomersAndGeographicAreasSummaryOfCustomersRevenueAndAccountsReceivableParentheticalDetail" id="DisclosureConcentrationsSignificantCustomersAndGeographicAreasSummaryOfCustomersRevenueAndAccountsReceivableParentheticalDetail">
        <link:definition>41403 - Disclosure - CONCENTRATIONS, SIGNIFICANT CUSTOMERS AND GEOGRAPHIC AREAS - Summary of customers revenue and accounts receivable - (Parenthetical) (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureConcentrationsSignificantCustomersAndGeographicAreasAdditionalInformationDetail" id="DisclosureConcentrationsSignificantCustomersAndGeographicAreasAdditionalInformationDetail">
        <link:definition>41404 - Disclosure - CONCENTRATIONS, SIGNIFICANT CUSTOMERS AND GEOGRAPHIC AREAS - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureNetLossPerShareScheduleOfEarningsPerShareBasicAndDilutedDetail" id="DisclosureNetLossPerShareScheduleOfEarningsPerShareBasicAndDilutedDetail">
        <link:definition>41501 - Disclosure - NET LOSS PER SHARE - Schedule of Earnings Per Share Basic and Diluted (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureNetLossPerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetail" id="DisclosureNetLossPerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetail">
        <link:definition>41502 - Disclosure - NET LOSS PER SHARE - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureNetLossPerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareParentheticalDetail" id="DisclosureNetLossPerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareParentheticalDetail">
        <link:definition>41503 - Disclosure - NET LOSS PER SHARE - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Parenthetical) (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureNetLossPerShareAdditionalInformationDetail" id="DisclosureNetLossPerShareAdditionalInformationDetail">
        <link:definition>41504 - Disclosure - NET LOSS PER SHARE - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRecentAccountingDevelopments" id="DisclosureRecentAccountingDevelopments">
        <link:definition>10201 - Disclosure - RECENT ACCOUNTING DEVELOPMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureBusinessCombination" id="DisclosureBusinessCombination">
        <link:definition>10301 - Disclosure - BUSINESS COMBINATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureEarnOutLiability" id="DisclosureEarnOutLiability">
        <link:definition>10401 - Disclosure - EARN-OUT LIABILITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureChangesInStockholdersEquityDeficit" id="DisclosureChangesInStockholdersEquityDeficit">
        <link:definition>10501 - Disclosure - CHANGES IN STOCKHOLDERS' EQUITY(DEFICIT)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureInvestments" id="DisclosureInvestments">
        <link:definition>10701 - Disclosure - INVESTMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureShareBasedCompensation" id="DisclosureShareBasedCompensation">
        <link:definition>10901 - Disclosure - SHARE-BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureConcentrationsSignificantCustomersAndGeographicAreas" id="DisclosureConcentrationsSignificantCustomersAndGeographicAreas">
        <link:definition>11401 - Disclosure - CONCENTRATIONS, SIGNIFICANT CUSTOMERS AND GEOGRAPHIC AREAS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRestructuringAndSeverance" id="DisclosureRestructuringAndSeverance">
        <link:definition>11701 - Disclosure - RESTRUCTURING AND SEVERANCE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureContingencies" id="DisclosureContingencies">
        <link:definition>11801 - Disclosure - CONTINGENCIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureBusinessCombinationTables" id="DisclosureBusinessCombinationTables">
        <link:definition>30303 - Disclosure - BUSINESS COMBINATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureEarnOutLiabilityTables" id="DisclosureEarnOutLiabilityTables">
        <link:definition>30403 - Disclosure - EARN-OUT LIABILITY (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureChangesInStockholdersEquityDeficitTables" id="DisclosureChangesInStockholdersEquityDeficitTables">
        <link:definition>30503 - Disclosure - CHANGES IN STOCKHOLDERS' EQUITY(DEFICIT) (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureInvestmentsTables" id="DisclosureInvestmentsTables">
        <link:definition>30703 - Disclosure - INVESTMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureFinancingArrangementsTables" id="DisclosureFinancingArrangementsTables">
        <link:definition>31003 - Disclosure - FINANCING ARRANGEMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRestructuringAndSeveranceTables" id="DisclosureRestructuringAndSeveranceTables">
        <link:definition>31803 - Disclosure - RESTRUCTURING AND SEVERANCE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureEarnOutLiabilityAdditionalInformationDetail" id="DisclosureEarnOutLiabilityAdditionalInformationDetail">
        <link:definition>40402 - Disclosure - EARN-OUT LIABILITY - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRestructuringAndSeveranceSummaryOfRestructuringActivitiesDetail" id="DisclosureRestructuringAndSeveranceSummaryOfRestructuringActivitiesDetail">
        <link:definition>41801 - Disclosure - RESTRUCTURING AND SEVERANCE - Summary of restructuring activities (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://www.rigetti.com/role/DisclosureRestructuringAndSeveranceAdditionalInformationDetail" id="DisclosureRestructuringAndSeveranceAdditionalInformationDetail">
        <link:definition>41802 - Disclosure - RESTRUCTURING AND SEVERANCE - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:type="simple" xlink:href="tmb-20230630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="tmb-20230630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="tmb-20230630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="tmb-20230630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:import namespace="http://fasb.org/us-roles/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-roles-2023.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/country/2023" schemaLocation="https://xbrl.sec.gov/country/2023/country-2023.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/dei/2023" schemaLocation="https://xbrl.sec.gov/dei/2023/dei-2023.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd" />
  <xsd:import namespace="http://fasb.org/us-gaap/2023" schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2023" schemaLocation="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd" />
  <xsd:element name="ForwardContractAssetsCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ForwardContractAssetsCurrent" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="DebtNetOfCurrentPortion" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_DebtNetOfCurrentPortion" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="TransactionCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_TransactionCosts" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="IssuanceOfCommonStockUponExerciseOfCommonStockWarrantsShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_IssuanceOfCommonStockUponExerciseOfCommonStockWarrantsShares" substitutionGroup="xbrli:item" />
  <xsd:element name="IssuanceOfCommonStockUponExerciseOfCommonStockWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_IssuanceOfCommonStockUponExerciseOfCommonStockWarrants" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="IssuanceOfCommonStockThroughBusinessCombinationAndPrivateInvestmentOfPublicEquityNetOfTransactionCostsAndDerivativeLiabilitiesValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_IssuanceOfCommonStockThroughBusinessCombinationAndPrivateInvestmentOfPublicEquityNetOfTransactionCostsAndDerivativeLiabilitiesValue" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="AdjustmentsToAdditionalPaidInCapitalExerciseOfLoanAndSecurityAgreementWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AdjustmentsToAdditionalPaidInCapitalExerciseOfLoanAndSecurityAgreementWarrants" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="AdjustmentsToAdditionalPaidInCapitalSettlementOfTheFirstTrancheOfForwardContract" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AdjustmentsToAdditionalPaidInCapitalSettlementOfTheFirstTrancheOfForwardContract" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="ReclassificationOfTemporaryEquityShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ReclassificationOfTemporaryEquityShares" substitutionGroup="xbrli:item" />
  <xsd:element name="IssuanceOfCommonStockThroughBusinessCombinationAndPrivateInvestmentOfPublicEquityNetOfTransactionCostsAndDerivativeLiabilitiesShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_IssuanceOfCommonStockThroughBusinessCombinationAndPrivateInvestmentOfPublicEquityNetOfTransactionCostsAndDerivativeLiabilitiesShares" substitutionGroup="xbrli:item" />
  <xsd:element name="IncreaseDecreaseInUnrealizedLossOnAvailableForSaleSecurities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_IncreaseDecreaseInUnrealizedLossOnAvailableForSaleSecurities" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="IncreaseDecreaseInAccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_IncreaseDecreaseInAccruedExpensesAndOtherCurrentLiabilities" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="AmortizationOfDebtCommitmentFeeAsset" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AmortizationOfDebtCommitmentFeeAsset" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="ChangeInFairValueOfForwardContract" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ChangeInFairValueOfForwardContract" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="AccretionOfDebtEndOfTermLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AccretionOfDebtEndOfTermLiabilities" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="NonCashLeaseExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_NonCashLeaseExpense" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="PaymentOfDeferredOfferingCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PaymentOfDeferredOfferingCosts" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="ProceedsFromBusinessCombinationNetOfTransactionCostsPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ProceedsFromBusinessCombinationNetOfTransactionCostsPaid" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="TransactionCostsPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_TransactionCostsPaid" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="PaymentOfLoanAndSecurityAgreementExitFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PaymentOfLoanAndSecurityAgreementExitFees" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="ProceedsFromIssuanceOfCommonStockUponExerciseOfStockOptionsAndWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ProceedsFromIssuanceOfCommonStockUponExerciseOfStockOptionsAndWarrants" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="CapitalizationOfDeferredCostsToEquityUponShareIssuance" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CapitalizationOfDeferredCostsToEquityUponShareIssuance" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="ExerciseOfLoanAndSecurityAgreementWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ExerciseOfLoanAndSecurityAgreementWarrants" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="SettlementOfTheFirstTrancheOfForwardContract" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_SettlementOfTheFirstTrancheOfForwardContract" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="InitialFairValueOfEarnoutLiabilityAcquiredInMergera" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_InitialFairValueOfEarnoutLiabilityAcquiredInMergera" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="InitialFairValueOfPrivatePlacementAndPublicWarrantsLiabilityAcquiredInMerger" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_InitialFairValueOfPrivatePlacementAndPublicWarrantsLiabilityAcquiredInMerger" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="PurchasesOfPropertyAndEquipmentRecordedInAccruedExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PurchasesOfPropertyAndEquipmentRecordedInAccruedExpense" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="CommonStockTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="WarrantsTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_WarrantsTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="DisclosureInTabularFormOfNetProceedsFromBusinessCombinationTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureInTabularFormOfNetProceedsFromBusinessCombinationTableTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="DisclosureInTabularFormOfReconciliationOfCommonStockSharesIssuedFollowingBusinessCombinationTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureInTabularFormOfReconciliationOfCommonStockSharesIssuedFollowingBusinessCombinationTableTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="ScheduleOfChangeInContractWithCustomerAssetAndLiabilityTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ScheduleOfChangeInContractWithCustomerAssetAndLiabilityTableTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="DisclosureOfVestingStatusOfWarrantsTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureOfVestingStatusOfWarrantsTableTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="PrivateWarrantMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_PrivateWarrantMember" substitutionGroup="xbrli:item" />
  <xsd:element name="FairValueLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_FairValueLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="ScheduleComputationOfEarningsPerShareBasicAndDilutedTableTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ScheduleComputationOfEarningsPerShareBasicAndDilutedTableTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="DescriptionOfOrganizationBusinessOperationsAndBasisOfPresentationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DescriptionOfOrganizationBusinessOperationsAndBasisOfPresentationTable" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="DescriptionOfOrganizationBusinessOperationsAndBasisOfPresentationLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DescriptionOfOrganizationBusinessOperationsAndBasisOfPresentationLineItems" substitutionGroup="xbrli:item" />
  <xsd:element name="EventAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_EventAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="EventDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_EventDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="ConversionOfCommonStockSharesFromThePreviousCompanyToTheCurrentCompanyMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ConversionOfCommonStockSharesFromThePreviousCompanyToTheCurrentCompanyMember" substitutionGroup="xbrli:item" />
  <xsd:element name="TrancheAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="TrancheDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="AgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AgreementAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="AgreementDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AgreementDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="IncreaseDecreaseInDeferredRent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_IncreaseDecreaseInDeferredRent" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="RigettiComputingIncMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RigettiComputingIncMember" substitutionGroup="xbrli:item" />
  <xsd:element name="NumberOfCustomersAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_NumberOfCustomersAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="NumberOfCustomersDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_NumberOfCustomersDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="CriteriaAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CriteriaAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="CriteriaDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CriteriaDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="PublicWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_PublicWarrantsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="PrivatePlacementWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_PrivatePlacementWarrantsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="RGTIAgreementNameAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RGTIAgreementNameAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="RgtiAgreementNameDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RgtiAgreementNameDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="ConditionAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ConditionAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="ConditionDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ConditionDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="CustomerCMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CustomerCMember" substitutionGroup="xbrli:item" />
  <xsd:element name="CustomerEMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CustomerEMember" substitutionGroup="xbrli:item" />
  <xsd:element name="CustomerFMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CustomerFMember" substitutionGroup="xbrli:item" />
  <xsd:element name="CustomerAMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CustomerAMember" substitutionGroup="xbrli:item" />
  <xsd:element name="CustomerBMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CustomerBMember" substitutionGroup="xbrli:item" />
  <xsd:element name="CustomerDMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CustomerDMember" substitutionGroup="xbrli:item" />
  <xsd:element name="DisclosureInTabularFormOfNetProceedsFromBusinessCombinationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureInTabularFormOfNetProceedsFromBusinessCombinationTable" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="DisclosureInTabularFormOfNetProceedsFromBusinessCombinationLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureInTabularFormOfNetProceedsFromBusinessCombinationLineItems" substitutionGroup="xbrli:item" />
  <xsd:element name="CashReceivedFromTrustNetOfRedemptions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CashReceivedFromTrustNetOfRedemptions" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="AggregateTransactionCostsPaid" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AggregateTransactionCostsPaid" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="CashReceivedFromPrivateInvestmentInPublicEquity" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CashReceivedFromPrivateInvestmentInPublicEquity" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="PaymentOfTransactionCostsThroughCash" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PaymentOfTransactionCostsThroughCash" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="AdjustmentToAdditionalPaidInCapitalBusinessCombinationTransactionCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_AdjustmentToAdditionalPaidInCapitalBusinessCombinationTransactionCosts" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="DisclosureInTabularFormOfReconciliationOfCommonStockSharesIssuedFollowingBusinessCombinationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureInTabularFormOfReconciliationOfCommonStockSharesIssuedFollowingBusinessCombinationTable" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="StatusOfSharesOutstandingBeforeBusinessCombinationMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_StatusOfSharesOutstandingBeforeBusinessCombinationMember" substitutionGroup="xbrli:item" />
  <xsd:element name="DisclosureInTabularFormOfReconciliationOfCommonStockSharesIssuedFollowingBusinessCombinationLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureInTabularFormOfReconciliationOfCommonStockSharesIssuedFollowingBusinessCombinationLineItems" substitutionGroup="xbrli:item" />
  <xsd:element name="StockSharesIssuedAggregateBusinessCombinationPrivateInvestmentInPublicEquity" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_StockSharesIssuedAggregateBusinessCombinationPrivateInvestmentInPublicEquity" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockSharesIssuedDueToExerciseOfStockOptionsImmediatelyBeforeClosing" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedDueToExerciseOfStockOptionsImmediatelyBeforeClosing" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockSharesIssuedInTheNewCompany" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedInTheNewCompany" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockSharesIssuedPursuantToPrivateInvestmentInPublicEquity" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedPursuantToPrivateInvestmentInPublicEquity" substitutionGroup="xbrli:item" />
  <xsd:element name="RedemptionOfCommonStockSharesOfThePredecessorCompany" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_RedemptionOfCommonStockSharesOfThePredecessorCompany" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockSharesIssuedDueToExerciseOfWarrantsImmediatelyBeforeClosing" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedDueToExerciseOfWarrantsImmediatelyBeforeClosing" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockSharesNewlyIssuedInThePredecessorCompany" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesNewlyIssuedInThePredecessorCompany" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockSharesIssuedInTheNewCompanyUponConversionOfTemporaryEquity" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockSharesIssuedInTheNewCompanyUponConversionOfTemporaryEquity" substitutionGroup="xbrli:item" />
  <xsd:element name="SeriesCRedeemableConvertiblePreferredStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_SeriesCRedeemableConvertiblePreferredStockMember" substitutionGroup="xbrli:item" />
  <xsd:element name="SeriesCOneRedeemableConvertiblePreferredStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_SeriesCOneRedeemableConvertiblePreferredStockMember" substitutionGroup="xbrli:item" />
  <xsd:element name="PromoteSponsorVestingSharesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_PromoteSponsorVestingSharesMember" substitutionGroup="xbrli:item" />
  <xsd:element name="SponsorRedemptionBasedVestingSharesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_SponsorRedemptionBasedVestingSharesMember" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockSharesExchangeRatio" type="xbrli:pureItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_CommonStockSharesExchangeRatio" substitutionGroup="xbrli:item" />
  <xsd:element name="ConversionFromTemporaryEquityToPermanentEquityExchangeRatio" type="xbrli:pureItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ConversionFromTemporaryEquityToPermanentEquityExchangeRatio" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockNumberOfVotesPerShare" type="xbrli:pureItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_CommonStockNumberOfVotesPerShare" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockSharesIssuedAsAResultOfExchange" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_CommonStockSharesIssuedAsAResultOfExchange" substitutionGroup="xbrli:item" />
  <xsd:element name="TemporaryEquityOfPreviousCompanyConvertedIntoPermanentEquityOfTheResultantCompanyParOrStatedValuePerShare" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_TemporaryEquityOfPreviousCompanyConvertedIntoPermanentEquityOfTheResultantCompanyParOrStatedValuePerShare" substitutionGroup="xbrli:item" />
  <xsd:element name="VolumeWeightedAveragePricePerShare" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_VolumeWeightedAveragePricePerShare" substitutionGroup="xbrli:item" />
  <xsd:element name="NumberOfTradingDaysForDeterminingTheSharePrice" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_NumberOfTradingDaysForDeterminingTheSharePrice" substitutionGroup="xbrli:item" />
  <xsd:element name="SharesSubjectToVestingMaximumPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_SharesSubjectToVestingMaximumPeriod" substitutionGroup="xbrli:item" />
  <xsd:element name="SharesSubjectToVestingBasedOnCertainConditions" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_SharesSubjectToVestingBasedOnCertainConditions" substitutionGroup="xbrli:item" />
  <xsd:element name="NumberOfConsecutiveTradingDaysForDeterminingTheSharePrice" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_NumberOfConsecutiveTradingDaysForDeterminingTheSharePrice" substitutionGroup="xbrli:item" />
  <xsd:element name="ClassOfWarrantsOrRightsOutstandingExercisePricePerShareOfTheResultingCompanyDueToBusinessCombination" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ClassOfWarrantsOrRightsOutstandingExercisePricePerShareOfTheResultingCompanyDueToBusinessCombination" substitutionGroup="xbrli:item" />
  <xsd:element name="ClassOfWarrantsOrRightsNumberOfSharesCoveredByEachWarrantsOrRightInTheResultingCompanyDueToBusinessCombinations" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ClassOfWarrantsOrRightsNumberOfSharesCoveredByEachWarrantsOrRightInTheResultingCompanyDueToBusinessCombinations" substitutionGroup="xbrli:item" />
  <xsd:element name="OneTimeBonus" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_OneTimeBonus" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="CommonStockOfPreviousCompanyConvertedIntoCurrentCompanyCommonStockParOrStatedValuePerShare" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_CommonStockOfPreviousCompanyConvertedIntoCurrentCompanyCommonStockParOrStatedValuePerShare" substitutionGroup="xbrli:item" />
  <xsd:element name="SponsorAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_SponsorAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element name="InitialSubscriptionAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_InitialSubscriptionAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element name="SubsequentSubscriptionAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_SubsequentSubscriptionAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element name="TrancheOneMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheOneMember" substitutionGroup="xbrli:item" />
  <xsd:element name="TrancheTwoMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheTwoMember" substitutionGroup="xbrli:item" />
  <xsd:element name="InvestorAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_InvestorAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="InvestorDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_InvestorDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="PrivateInvestmentInPublicEquityInvestorsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_PrivateInvestmentInPublicEquityInvestorsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="RevenuePerformanceObligationTransactionPriceAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RevenuePerformanceObligationTransactionPriceAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="RevenuePerformanceObligationTransactionPriceDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RevenuePerformanceObligationTransactionPriceDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="CollaborativeResearchAndOtherProfessionalServicesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CollaborativeResearchAndOtherProfessionalServicesMember" substitutionGroup="xbrli:item" />
  <xsd:element name="AccessToQuantumComputingSystemsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AccessToQuantumComputingSystemsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="RecognitionOfDeferredRevenues" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_RecognitionOfDeferredRevenues" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="DeferralOfRevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_DeferralOfRevenue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="CurrentPortionOfOutstandingPrincipalAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_CurrentPortionOfOutstandingPrincipalAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="AccruedFinalPaymentFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_AccruedFinalPaymentFee" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="CurrentPortionOfLongTermDebtGross" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_CurrentPortionOfLongTermDebtGross" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="TrancheBMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheBMember" substitutionGroup="xbrli:item" />
  <xsd:element name="TrancheAMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheAMember" substitutionGroup="xbrli:item" />
  <xsd:element name="TrancheCMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrancheCMember" substitutionGroup="xbrli:item" />
  <xsd:element name="LoanAndSecurityAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_LoanAndSecurityAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element name="DebtInstrumentPaymentFeepercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_DebtInstrumentPaymentFeepercentage" substitutionGroup="xbrli:item" />
  <xsd:element name="WithdrawnCreditFacility" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_WithdrawnCreditFacility" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="PercentageOfDebtRelatedCostPaidUponTheConsummationOfMerger" type="xbrli:pureItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PercentageOfDebtRelatedCostPaidUponTheConsummationOfMerger" substitutionGroup="xbrli:item" />
  <xsd:element name="InvestorNameAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_InvestorNameAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="InvestorNameDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_InvestorNameDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="VentureCapitalMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_VentureCapitalMember" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockWarrantsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="EquityAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_EquityAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="EquityDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_EquityDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="PercentageOfTotalAggregateNumberOrVolumeOfSharesOfCommonStockTradedOnTheNasdaqCapitalMarket" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PercentageOfTotalAggregateNumberOrVolumeOfSharesOfCommonStockTradedOnTheNasdaqCapitalMarket" substitutionGroup="xbrli:item" />
  <xsd:element name="PercentageOfTheAggregateNumberOfSharesOfCommonStockIssuedAndOutstandingImmediatelyPriorToTheExecutionOfTheAgreement" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PercentageOfTheAggregateNumberOfSharesOfCommonStockIssuedAndOutstandingImmediatelyPriorToTheExecutionOfTheAgreement" substitutionGroup="xbrli:item" />
  <xsd:element name="AgreementNameAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AgreementNameAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="AgreementNameDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AgreementNameDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="CommonStockPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CommonStockPurchaseAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element name="WarrantsToPurchaseClassACommonStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_WarrantsToPurchaseClassACommonStockMember" substitutionGroup="xbrli:item" />
  <xsd:element name="CustomerWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_CustomerWarrantsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="TrinityWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TrinityWarrantsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="ClassOfInvestorsAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ClassOfInvestorsAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="ClassOfInvestorsDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ClassOfInvestorsDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="Classofwarrantsorrightswarrantsissuedduringtheperiodunits" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_Classofwarrantsorrightswarrantsissuedduringtheperiodunits" substitutionGroup="xbrli:item" />
  <xsd:element name="Classofwarrantsorrightsaggregatefairvalueofwarrantsatthetimeofgrant" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_Classofwarrantsorrightsaggregatefairvalueofwarrantsatthetimeofgrant" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="Classofwarrantsvestingpercentage" type="xbrli:pureItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_Classofwarrantsvestingpercentage" substitutionGroup="xbrli:item" />
  <xsd:element name="WaitingPeriodAfterWhichTheShareTradingDaysAreConsidered" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_WaitingPeriodAfterWhichTheShareTradingDaysAreConsidered" substitutionGroup="xbrli:item" />
  <xsd:element name="ClassOfWarrantOrRightGrandDateFairValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ClassOfWarrantOrRightGrandDateFairValue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="Classofwarrantorrightissuedduringperiodwarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_Classofwarrantorrightissuedduringperiodwarrants" substitutionGroup="xbrli:item" />
  <xsd:element name="AtinitialrecognitionMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AtinitialrecognitionMember" substitutionGroup="xbrli:item" />
  <xsd:element name="DisclosureofvestingstatusofwarrantsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureofvestingstatusofwarrantsAbstract" substitutionGroup="xbrli:item" />
  <xsd:element name="DisclosureOfVestingStatusOfWarrantsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureOfVestingStatusOfWarrantsTable" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="StatusOfVestingAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_StatusOfVestingAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="StatusOfVestingDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_StatusOfVestingDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="VestedCustomerWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_VestedCustomerWarrantsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="UnvestedCustomerWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_UnvestedCustomerWarrantsMember" substitutionGroup="xbrli:item" />
  <xsd:element name="DisclosureofvestingstatusofwarrantsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DisclosureofvestingstatusofwarrantsLineItems" substitutionGroup="xbrli:item" />
  <xsd:element name="StockIssuedDuringPeriodWarrantsIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_StockIssuedDuringPeriodWarrantsIssued" substitutionGroup="xbrli:item" />
  <xsd:element name="ClassOfWarrantsOrRightsWarrantsIssuedDuringThePeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_ClassOfWarrantsOrRightsWarrantsIssuedDuringThePeriod" substitutionGroup="xbrli:item" />
  <xsd:element name="AmpereComputingLlcMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_AmpereComputingLlcMember" substitutionGroup="xbrli:item" />
  <xsd:element name="RigettiMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RigettiMember" substitutionGroup="xbrli:item" />
  <xsd:element name="ForwardWarrantAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ForwardWarrantAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element name="MeasurementInputProbabilityOfOccurringTheContingencyMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_MeasurementInputProbabilityOfOccurringTheContingencyMember" substitutionGroup="xbrli:item" />
  <xsd:element name="ContingentEarnOutLiabilityMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ContingentEarnOutLiabilityMember" substitutionGroup="xbrli:item" />
  <xsd:element name="ForwardWarrantAgreementFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ForwardWarrantAgreementFairValueDisclosure" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="ContingentEarnOutLiabilityFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="rgti_ContingentEarnOutLiabilityFairValueDisclosure" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="ForwardWarrantAgreementLiabilityFairValueDisclosureMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ForwardWarrantAgreementLiabilityFairValueDisclosureMember" substitutionGroup="xbrli:item" />
  <xsd:element name="DerivativeWarrantLiabilitiesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_DerivativeWarrantLiabilitiesMember" substitutionGroup="xbrli:item" />
  <xsd:element name="ScheduleOfShareBasedCompensationRestrictedStockAndRestrictedStockUnitsActivityAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ScheduleOfShareBasedCompensationRestrictedStockAndRestrictedStockUnitsActivityAbstract" substitutionGroup="xbrli:item" />
  <xsd:element name="RestrictedStockUnitsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_RestrictedStockUnitsTable" substitutionGroup="xbrldt:hypercubeItem" />
  <xsd:element name="ScheduleOfShareBasedCompensationRestrictedStockAndRestrictedStockUnitsActivityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_ScheduleOfShareBasedCompensationRestrictedStockAndRestrictedStockUnitsActivityLineItems" substitutionGroup="xbrli:item" />
  <xsd:element name="TwoThousandTwentyTwoEquityIncentivePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_TwoThousandTwentyTwoEquityIncentivePlanMember" substitutionGroup="xbrli:item" />
  <xsd:element name="PercentageOfTheCommonStockOfAllClassesOutstandingOnPrecedingYear" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PercentageOfTheCommonStockOfAllClassesOutstandingOnPrecedingYear" substitutionGroup="xbrli:item" />
  <xsd:element name="PeriodAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_PeriodAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="PeriodDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_PeriodDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="NumberOfEmployees" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_NumberOfEmployees" substitutionGroup="xbrli:item" />
  <xsd:element name="PercentageOfReductionInEmployees" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="rgti_PercentageOfReductionInEmployees" substitutionGroup="xbrli:item" />
  <xsd:element name="WeightedAverageSharePriceAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_WeightedAverageSharePriceAxis" substitutionGroup="xbrldt:dimensionItem" />
  <xsd:element name="WeightedAverageSharePriceDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="rgti_WeightedAverageSharePriceDomain" substitutionGroup="xbrli:item" />
  <xsd:element name="EarnoutLiabilityAbstract." id="rgti_EarnoutLiabilityAbstract." type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestructuringAndSeveranceDisclosureTextBlock" id="rgti_RestructuringAndSeveranceDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DisclosureOfEarnoutLiabilityTextBlock" id="rgti_DisclosureOfEarnoutLiabilityTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ImpairmentOfDeferredOfferingCosts" id="rgti_ImpairmentOfDeferredOfferingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AdjustmentToAdditionalPaidInCapitalBusinessCombinationProceedsNetOfTransactionCosts" id="rgti_AdjustmentToAdditionalPaidInCapitalBusinessCombinationProceedsNetOfTransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="Adjustmenttoadditionalpaidincapitaladjustmentforwarrantliabilities" id="rgti_Adjustmenttoadditionalpaidincapitaladjustmentforwarrantliabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AdjustmentToAdditionalPaidInCapitalEarnoutLiabilities" id="rgti_AdjustmentToAdditionalPaidInCapitalEarnoutLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="MeasurementInputEstimatedProbabilityOfOccurrenceMember" id="rgti_MeasurementInputEstimatedProbabilityOfOccurrenceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ForwardWarrantMember" id="rgti_ForwardWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="U.s.GovernmentAgencyBondsMember" id="rgti_U.s.GovernmentAgencyBondsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ConcentrationRiskThresholdPercentage" id="rgti_ConcentrationRiskThresholdPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ForwardWarrantAgreementDisclosureTextBlock" id="rgti_ForwardWarrantAgreementDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ForwardWarrantAgreementAbstract" id="rgti_ForwardWarrantAgreementAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsStockPrice" id="rgti_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsStockPrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsStrikePrice" id="rgti_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsStrikePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PrivateWarrantsMember" id="rgti_PrivateWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSimulatedTradingDays" id="rgti_ShareBasedCompensationArrangementByShareBasedPaymentAwardSimulatedTradingDays" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodFairValue" id="rgti_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DeferredAssetsInConnectionWithWarrantsIssuedToCustomer" id="rgti_DeferredAssetsInConnectionWithWarrantsIssuedToCustomer" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="TimeBasedVestingRestrictedStockUnitsMember" id="rgti_TimeBasedVestingRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareTriggeringEventAxis" id="rgti_ShareTriggeringEventAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareTriggeringEventDomain" id="rgti_ShareTriggeringEventDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SharePriceEqualOrExceedsAboveDollarTwoPerShareMember" id="rgti_SharePriceEqualOrExceedsAboveDollarTwoPerShareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SharePriceEqualOrExceedsAboveDollarFourPerShareMember" id="rgti_SharePriceEqualOrExceedsAboveDollarFourPerShareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfTradingDaysWithinWhichAwardWillBeVested" id="rgti_NumberOfTradingDaysWithinWhichAwardWillBeVested" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfConsecutiveTradingDaysWithinWhichAwardWillBeVested" id="rgti_NumberOfConsecutiveTradingDaysWithinWhichAwardWillBeVested" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="MarketBasedVestingRestrictedStockUnitsMember" id="rgti_MarketBasedVestingRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PurchaseAgreementImpairmentOfDeferredFinancingCosts" id="rgti_PurchaseAgreementImpairmentOfDeferredFinancingCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PostConversionMember" id="rgti_PostConversionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MeasurementInputSimulatedTradingDaysMember" id="rgti_MeasurementInputSimulatedTradingDaysMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FairValueLiabilitiesTransfersInOutLevel3Amount" id="rgti_FairValueLiabilitiesTransfersInOutLevel3Amount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="FairValueLiabilitiesLevel3ToLevel1TransfersNumberOfWarrants" id="rgti_FairValueLiabilitiesLevel3ToLevel1TransfersNumberOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="GainLossOnTransfersInOutLevel3FairValueLiability" id="rgti_GainLossOnTransfersInOutLevel3FairValueLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SupernovaAcquisitionMember" id="rgti_SupernovaAcquisitionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TwoThousandAndTwentyThreeMember" id="rgti_TwoThousandAndTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TwoThousandTwentyFourMember" id="rgti_TwoThousandTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
